Zinc pyrithione

Catalog Number	ACM13463417-2
CAS	13463-41-7
Structure
Description	Pyrithione zinc, also commonly known as zinc pyrithione, has antibacterial, antimicrobial, and antifungal properties that can help treat seborrheic dermatitis (also called dandruff), scalp psoriasis, and acne.
Synonyms	ZPT
IUPAC Name	Zinc;1-oxidopyridin-1-ium-2-thiolate
Molecular Weight	317.40
Molecular Formula	C10H8N2O2S2Zn
Canonical SMILES	C1=CC=[N+](C(=C1)[S-])[O-].C1=CC=[N+](C(=C1)[S-])[O-].[Zn+2]
InChI	InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;+2/p-2
InChI Key	OTPSWLRZXRHDNX-UHFFFAOYSA-L
Melting Point	240 ℃
Purity	98%
Density	1.782 g/cm3
Solubility	insoluble (<0.1 g/100 mL at 21 ºC)
Appearance	White to slight yellow powder or white suspension
Application	ZPT-50 is the most important antidandruf agent in the world, which used for more than 30 years in shampoo. ZPT-50 shows excellent inhibiting effect on pytyrosporum ovale that causes dandruff. ZPT has broad spectrum bactericide and marine antifouling material, and is well used for cosmetic, shampoo, skins medicine, adhesive and coating painting and so on.
Storage	Content is unchanged in two years.
Complexity	183
Covalently-Bonded Unit Count	3
Defined Atom Stereocenter Count	0
EC Number	236-671-3
Exact Mass	315.931862
Formal Charge	0
Heavy Atom Count	17
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	0
Loss On Drying	0.5%
Monoisotopic Mass	315.931862
pH	6.5-8.5 (5% solution)
Properties	Low solubility in water
Rotatable Bond Count	2
Topological Polar Surface Area	52.9 Ų

Q&A

What is the chemical formula of Zinc pyrithione?

The chemical formula of Zinc pyrithione is C10H8N2O2S2Zn.

What is the melting point of Zinc pyrithione?

The melting point of Zinc pyrithione is approximately 240°C.

What is the water solubility of Zinc pyrithione?

Zinc pyrithione is insoluble in water (<0.1 g/100 mL at 21°C).

How is Zinc pyrithione described in terms of odor?

Zinc pyrithione is described as having a mild characteristic odor.

What are the safety hazards associated with Zinc pyrithione?

Zinc pyrithione is classified as a T+, N, and T hazard according to hazard codes.

What is the primary use of Zinc pyrithione in cosmetics?

Zinc pyrithione is used as an antifungal, antibacterial, and antiseborrheic agent in shampoos and hair creams.

What is the role of Zinc pyrithione in pharmaceutical applications?

Zinc pyrithione is a regulator of keratinization and has antimicrobial properties, making it effective in treating conditions like dandruff.

How does Zinc pyrithione react with surfactants?

Zinc pyrithione reacts with cationic and non-ionic surfactants, forming insoluble precipitates.

What are the toxicity evaluations of Zinc pyrithione on aquatic organisms?

Zinc pyrithione is toxic to aquatic organisms, with L(E)C50 values in the range of 3-300 µg/L.

What is the recommended concentration of Zinc pyrithione in cosmetics according to EEC and GB7916-87?

The maximum allowable concentration of Zinc pyrithione in cosmetics is 0.5%, with a general concentration range of 250-1000 mg/kg.